Can a Low-Carbohydrate Diet Improve Exercise Tolerance in Mcardle Disease?

McArdle disease is a rare disorder of skeletal muscle carbohydrate metabolism, with an estimated prevalence between 1: 100,0001:167,000 [1]. Affected individuals have mutations in both alleles of the PYGM gene, which encodes myophosphorylase, the skeletal muscle isoform of glycogen phosphorylase. McArdle disease is equally represented in both sexes and is inherited in an autosomal recessive manner [2]. A cardinal symptom of this metabolic myopathy is exercise intolerance, which is manifested by myalgia, untimely fatigue, stiffness and weakness of involved muscles, dyspnea and tachycardia upon exertion [3]. An interesting and universal objective phenomenon associated with Received: November 14, 2016; Accepted: February 01, 2017; Published: February 06, 2017 Abstract